Objective: To investigate the spatiotemporal distribution pattern of activated ERK1/ 2 and gliosis in mice hippocampal formation following pilocarpine-induced seizures and to discuss the role of ERK1/ 2 signaling pathway in gliosis of mice with epilepsy. 目的:探讨匹罗卡品致痫小鼠海马中细胞外信号调节激酶(ERK1/2)活化的规律、胶质细胞增生情况以及ERK1/2信号转导通路在胶质细胞增生中的作用。
The role of astrocytes activated by tnf α in the relapse of chronic epilepsy TNFα激活的星形胶质细胞在慢性癫痫复发中的作用
Early activated neuroglias could release a large amounts of inflammatory cytokines after KA-induced seizures, which affected the occurrence and development of epilepsy and regulated the activity of neurons. KA致痫后,早期活化的胶质细胞释放大量的炎性细胞因子,影响癫痫的进一步发生和发展以及调节神经元的活动。